Water → Methyl 1-((3-amino-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate

HRID 295783Notes

Reaction equation

HRID 295783 reaction equation
[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[H:46][H:47].[N+:1]([O-:2])(=[O:3])[c:4]1[cH:5][c:6]([CH2:28][N:29]2[CH2:30][CH:31]([C:33](=[O:34])[O:35][CH3:36])[CH2:32]2)[cH:7][cH:8][c:9]1-[c:10]1[s:11][c:12]2[n:13][c:14]([C:19]3([c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[CH2:20][CH2:21]3)[cH:15][cH:16][c:17]2[n:18]1.[OH2:48]>>[NH2:1][c:4]1[cH:5][c:6]([CH2:28][N:29]2[CH2:30][CH:31]([C:33](=[O:34])[O:35][CH3:36])[CH2:32]2)[cH:7][cH:8][c:9]1-[c:10]1[s:11][c:12]2[n:13][c:14]([C:19]3([c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[CH2:20][CH2:21]3)[cH:15][cH:16][c:17]2[n:18]1

Participants

5

Reactant 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 67112881HCID 67112881, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67111429Methyl 1-((3-amino-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate

Sources & evidence

ORD record
ord-b325a81afffd4ab0b4e36e899c80e599
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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