Tetrahydrofuran → 2-Chloro-4-(4-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester

HRID 295926Notes

Reaction equation

HRID 295926 reaction equation
[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[Cl:1][c:2]1[s:3][cH:4][c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1.[Cl:22][C:23](=[O:24])[O:25][CH2:26][CH3:27].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[Cl:1][c:2]1[s:3][c:4]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 10928Ethyl chloroformateHCID 214086242-Chloro-4-[4-(trifluoromethyl)phenyl]-1,3-thiazoleHCID 178418339Butyllithium

Product 1

HCID 674273002-Chloro-4-(4-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-00ddb625cc30478480475d1827fe780c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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