Dimethylformamide → Methyl 6-(2-fluorophenyl)-5'-methyl-3,3'-bipyridine-5-carboxylate

HRID 297064Notes

Reaction equation

HRID 297064 reaction equation
[C:29](=[O:30])([O-:31])[O-:32].[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[Cl:1][c:2]1[c:3]([C:15](=[O:16])[O:17][CH3:18])[cH:4][c:5](-[c:8]2[cH:9][n:10][cH:11][c:12]([CH3:14])[cH:13]2)[cH:6][n:7]1.[Cs+:33].[Cs+:34].[F:19][c:20]1[c:21]([B:26]([OH:27])[OH:28])[cH:22][cH:23][cH:24][cH:25]1>>[c:2]1(-[c:21]2[c:20]([F:19])[cH:25][cH:24][cH:23][cH:22]2)[c:3]([C:15](=[O:16])[O:17][CH3:18])[cH:4][c:5](-[c:8]2[cH:9][n:10][cH:11][c:12]([CH3:14])[cH:13]2)[cH:6][n:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27343542-Fluorophenylboronic acidHCID 58539034Methyl 6-chloro-5'-methyl-3,3'-bipyridine-5-carboxylate

Product 1

HCID 58539049Methyl 6-(2-fluorophenyl)-5'-methyl-3,3'-bipyridine-5-carboxylate

Sources & evidence

ORD record
ord-6910637085b342d39a62266d477ef24b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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