HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 6-Bromohexyl cinnamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| Reactant | 6-Bromo-1-hexanol | HCID 77970 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-Bromohexyl cinnamate | HCID 68849628 | 53% |
Reaction Steps
7 g of 6-bromohexanol was dissolved in a mixed solution of 5 ml of triethylamine as base and 50 ml of THF, and then, cinnamoyl chloride was added dropwise thereto at 0° C. The resultant was filtered to remove the solvent and the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5) to obtain 8 g of 6-bromohexyl cinnamate (yield: 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07422778B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-6c427d124c894c5b946a8d05df74ed6e |
| Source note | uspto-grants-2008_09 |