Acetic Acid → 7-methoxy-1-(2-(4-(((4-methoxy-5-methylpyridin-2-yl)methyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one

HRID 297760Notes

Reaction equation

HRID 297760 reaction equation
[C:40]([BH3-:41])#[N:42].[C:44](=[O:45])([O-:46])[OH:47].[CH3:12][OH:13].[CH3:14][O-:15].[CH3:1][O:2][c:3]1[cH:4][c:5]([CH:10]=[O:11])[n:6][cH:7][c:8]1[CH3:9].[CH3:49][OH:50].[CH3:55][C:56](=[O:57])[OH:58].[CH:51]([Cl:52])([Cl:53])[Cl:54].[ClH:17].[NH2:18][CH:19]1[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][n:27]2[c:28](=[O:39])[cH:29][cH:30][c:31]3[n:32][cH:33][c:34]([O:37][CH3:38])[cH:35][c:36]23)[CH2:23][CH2:24]1.[Na+:16].[Na+:43].[Na+:48]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:10][NH:18][CH:19]2[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][n:27]3[c:28](=[O:39])[cH:29][cH:30][c:31]4[n:32][cH:33][c:34]([O:37][CH3:38])[cH:35][c:36]34)[CH2:23][CH2:24]2)[n:6][cH:7][c:8]1[CH3:9]

Participants

11

Reactant 10

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 887Methanol2×HCID 923Sodium ion3×HCID 6212ChloroformHCID 498716Cyano-borohydrideHCID 3826051MethoxideHCID 578151881-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-oneHCID 578154004-Methoxy-5-methylpyridine-2-carbaldehyde

Product 1

HCID 578151937-methoxy-1-(2-(4-(((4-methoxy-5-methylpyridin-2-yl)methyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-718027650f5e4258b643c55864f7d34d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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