反应详情

1.65 g (72 mmol) sodium are dissolved in 80 mL ethanol. 8.89 g (72 mmol) ethyl acetimidate hydrochloride in 160 mL ethanol are added at ambient temperature and the precipitated sodium chloride is filtered off. The filtrate is combined with 6.00 g (40 mmol) 4-methyl-benzoic acid hydrazide and stirred overnight. The reaction mixture is evaporated down and cooled. The precipitated solid is filtered off and washed with cold ethanol and diethyl ether (5.7 g white solid). A further 1.2 g solid are obtained from the filtrate after distillation of the solvents and recrystallisation from ethanol.

1. filtrationthe precipitated sodium chloride is filtered off
2. customThe reaction mixture is evaporated down
3. temperaturecooled
4. filtrationThe precipitated solid is filtered off
5. washwashed with cold ethanol and diethyl ether (5.7 g white solid)