Acetate → 4-Fluoro-4'-hydroxybiphenyl

HRID 297994Notes

Reaction equation

HRID 297994 reaction equation
[BH:9]([OH:10])[OH:11].[F:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[I:1][c:2]1[cH:3][cH:4][c:5]([OH:8])[cH:6][cH:7]1.[K+:19].[K+:20].[O-:21][C:22]([O-:23])=[O:24].[O-:33][C:34]([CH3:35])=[O:36].[O-:37][C:38]([CH3:39])=[O:40].[O:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1.[OH2:25].[Pd+2:32]>>[c:2]1(-[c:16]2[cH:15][cH:14][c:13]([F:12])[cH:18][cH:17]2)[cH:3][cH:4][c:5]([OH:8])[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 813Potassium Cation2×HCID 962WaterHCID 10008FluorobenzeneHCID 108944-IodophenolHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 61668Boronic AcidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

Product 1

HCID 3454204-Fluoro-4'-hydroxybiphenyl

Sources & evidence

ORD record
ord-6c628d4e7f234f03b884c03b8cee8718
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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