Trifluoroacetate → 4-{1-Hydroxy-2-[1-(4-methoxy-benzyl)-cyclopropylamino]-ethyl}-2-hydroxymethyl-phenol

HRID 29847Notes

Reaction equation

HRID 29847 reaction equation
C([O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19](=[O:25])[CH:20](OCC)O)=[CH:15][C:10]=1[C:11]([O:13]C)=O)C1C=CC=CC=1.[CH3:26][O:27][C:28]1[CH:38]=[CH:37][C:31]([CH2:32][C:33]2([NH2:36])[CH2:35][CH2:34]2)=[CH:30][CH:29]=1.FC(F)(F)C([O-])=O>>[OH:25][CH:19]([C:16]1[CH:17]=[CH:18][C:9]([OH:8])=[C:10]([CH2:11][OH:13])[CH:15]=1)[CH2:20][NH:36][C:33]1([CH2:32][C:31]2[CH:37]=[CH:38][C:28]([O:27][CH3:26])=[CH:29][CH:30]=2)[CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 231060921-(4-Methoxybenzyl)cyclopropanamineHCID 68858509Methyl benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate

Product 1

HCID 231061264-{1-Hydroxy-2-[1-(4-methoxy-benzyl)-cyclopropylamino]-ethyl}-2-hydroxymethyl-phenol

Procedure

Prepared according to general method 5 from 344 mg (1 mmol) methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate and 177 mg (1 mmol) 1-(4-methoxy-benzyl)-cyclopropylamine. Yield: 123 mg (27%, trifluoroacetate); mass spectroscopy: [M+H]+=344.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6c3bc8c1d7324940a10d9e8e4ab59f9d
Source dataset
uspto-grants-2008_09
Patent number
US07423035B2

Reaction notes

Loading…