HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(5-{2-[1-(4-fluoro-benzyl)-cyclopentylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulphonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide | HCID 10317570 | — |
| Reactant | 1-(4-Fluoro-benzyl)-cyclopentylamine hydrochloride | HCID 23106128 | — |
| Product | N-(5-{2-[1-(4-fluoro-benzyl)-cyclopentylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulphonamide | HCID 59789253 | — |
Reaction Steps
Prepared from 645 mg (1.70 mmol) N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide and 414 mg (1.70 mmol) 1-(4-fluoro-benzyl)-cyclopentylamine hydrochloride according to general method 6. Yield: 485 mg (62%, hydrochloride). Mass spectroscopy: [M+H]+=423.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423035B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-5308b75df2c94c53b1662196edcfaff3 |
| Source note | uspto-grants-2008_09 |