Hydrochloric Acid → N-(5-{2-[1-(4-fluoro-benzyl)-cyclopentylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulphonamide

HRID 29855Notes

Reaction equation

HRID 29855 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH:16](OCC)O)=[CH:11][C:10]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24])C1C=CC=CC=1.Cl.[F:28][C:29]1[CH:41]=[CH:40][C:32]([CH2:33][C:34]2([NH2:39])[CH2:38][CH2:37][CH2:36][CH2:35]2)=[CH:31][CH:30]=1.Cl>>[F:28][C:29]1[CH:30]=[CH:31][C:32]([CH2:33][C:34]2([NH:39][CH2:16][CH:15]([C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:11]=3)[OH:21])[CH2:38][CH2:37][CH2:36][CH2:35]2)=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10317570N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamideHCID 231061281-(4-Fluoro-benzyl)-cyclopentylamine hydrochloride

Product 1

HCID 59789253N-(5-{2-[1-(4-fluoro-benzyl)-cyclopentylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulphonamide

Procedure

Prepared from 645 mg (1.70 mmol) N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide and 414 mg (1.70 mmol) 1-(4-fluoro-benzyl)-cyclopentylamine hydrochloride according to general method 6. Yield: 485 mg (62%, hydrochloride). Mass spectroscopy: [M+H]+=423.

Sources & evidence

ORD record
ord-5308b75df2c94c53b1662196edcfaff3
Source dataset
uspto-grants-2008_09
Patent number
US07423035B2

Reaction notes

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