Hydrochloric Acid → N-(2-hydroxy-5-{1-hydroxy-2-[1-(4-methoxy-benzyl)-cyclopentylamino]-ethyl}-phenyl)-methanesulphonamide

HRID 29856Notes

Reaction equation

HRID 29856 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH:16](OCC)O)=[CH:11][C:10]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24])C1C=CC=CC=1.Cl.[CH3:28][O:29][C:30]1[CH:42]=[CH:41][C:33]([CH2:34][C:35]2([NH2:40])[CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:32][CH:31]=1.Cl>>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([OH:21])[CH2:16][NH:40][C:35]2([CH2:34][C:33]3[CH:41]=[CH:42][C:30]([O:29][CH3:28])=[CH:31][CH:32]=3)[CH2:36][CH2:37][CH2:38][CH2:39]2)=[CH:11][C:10]=1[NH:22][S:23]([CH3:26])(=[O:24])=[O:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10317570N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamideHCID 231060831-(4-Methoxy-benzyl)-cyclopentylamine hydrochloride

Product 1

HCID 23106109N-(2-hydroxy-5-{1-hydroxy-2-[1-(4-methoxy-benzyl)-cyclopentylamino]-ethyl}-phenyl)-methanesulphonamide

Procedure

Prepared from 645 mg (1.70 mmol) N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide and 411 mg (1.70 mmol) 1-(4-methoxy-benzyl)-cyclopentylamine hydrochloride according to general method 6. Yield: 369 mg (46%, hydrochloride). Mass spectroscopy: [M+H]+=435.

Sources & evidence

ORD record
ord-a1934d61576d47edb3b842ecd1cf94ac
Source dataset
uspto-grants-2008_09
Patent number
US07423035B2

Reaction notes

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