4-Pentynoic acid → 5-[2-Amino-4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-pent-4-ynoic acid

HRID 298732Notes

Reaction equation

HRID 298732 reaction equation
[C:24]([CH2:25][CH2:26][C:27]#[CH:28])(=[O:29])[OH:30].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[I:12]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[C:28]#[C:27][CH2:26][CH2:25][C:24](=[O:29])[OH:30]

Participants

3

Reactant 2

HCID 224644-Pentynoic acidHCID 442289644-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Product 1

HCID 577138425-[2-Amino-4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-pent-4-ynoic acid

Sources & evidence

ORD record
ord-d49c1c2a4ae5482494bc8531470e1610
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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