Methanol → N-(1-amino-3-cyclohexylpropan-2-yl)-4-(4-bromo-1-methylpyrazol-5-yl)-5-chlorothiophene-2-carboxamide

HRID 298796Notes

Reaction equation

HRID 298796 reaction equation
[Br:1][c:2]1[cH:3][n:4][n:5]([CH3:36])[c:6]1-[c:7]1[cH:8][c:9]([C:13](=[O:14])[NH:15][CH:16]([CH2:17][CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:24][N:25]2[C:26](=[O:27])[c:28]3[c:29]([cH:30][cH:31][cH:32][cH:33]3)[C:34]2=[O:35])[s:10][c:11]1[Cl:12].[CH3:44][OH:45].[NH2:37][NH2:38].[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[Br:1][c:2]1[cH:3][n:4][n:5]([CH3:36])[c:6]1-[c:7]1[cH:8][c:9]([C:13](=[O:14])[NH:15][CH:16]([CH2:17][CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:24][NH2:25])[s:10][c:11]1[Cl:12]

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 9321HydrazineHCID 765765704-(4-bromo-1-methylpyrazol-5-yl)-5-chloro-N-[1-cyclohexyl-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]thiophene-2-carboxamide

Product 1

HCID 69096449N-(1-amino-3-cyclohexylpropan-2-yl)-4-(4-bromo-1-methylpyrazol-5-yl)-5-chlorothiophene-2-carboxamide

Sources & evidence

ORD record
ord-baa7acf5043a48bb8f1bcc005e6ce81d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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