4-Fluorobenzyl bromide → 4-[(4-Fluorobenzyl)oxy]-6-isopropyl-2-(3-nitrophenyl)pyrimidine

HRID 29905Notes

Reaction equation

HRID 29905 reaction equation
[CH:1]([C:4]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[N:7]=[C:6]([OH:19])[CH:5]=1)([CH3:3])[CH3:2].[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][O:19][C:6]2[CH:5]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:9]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=3)[N:7]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 178439455HCID 178439455, compound2×

Product 1

HCID 99762244-[(4-Fluorobenzyl)oxy]-6-isopropyl-2-(3-nitrophenyl)pyrimidine

Procedure

The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and 4-fluorobenzyl bromide according to Method A; LC retention time 4.01 min: MS: m/z (ESI) 368 (M+H)

Sources & evidence

ORD record
ord-5baea2d5281d4f12a4851b9d66e69b6a
Source dataset
uspto-grants-2008_09
Patent number
US07423044B2

Reaction notes

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