Methyl 4-(bromomethyl)benzoate bromide → 4-({[2-(3,5-Dichlorophenyl)-6-isopropylpyrimidin-4-yl]oxy}methyl)benzoic acid

HRID 29914Notes

Reaction equation

HRID 29914 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([OH:15])[CH:12]=[C:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[Br-].Br[CH2:21][C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28]C)=[O:27])=[CH:24][CH:23]=1>>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]2[N:14]=[C:13]([O:15][CH2:21][C:22]3[CH:31]=[CH:30][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=3)[CH:12]=[C:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 86592754Methyl 4-(bromomethyl)benzoate bromideHCID 178439458HCID 178439458, compound2×

Product 1

HCID 100705704-({[2-(3,5-Dichlorophenyl)-6-isopropylpyrimidin-4-yl]oxy}methyl)benzoic acid

Procedure

The title compound was prepared from 2-(3,5-dichloro-phenyl)-6-isopropyl-pyrimidin-4-ol (which was obtained in Intermediate 6) and methyl 4-(bromomethyl)benzoate bromide according to Method A and Method B; LC retention time 4.11 min; MS: m/z (ESI) 415 (M−H).

Sources & evidence

ORD record
ord-e9a48ffa529e4ecc85d749ab8be3e47e
Source dataset
uspto-grants-2008_09
Patent number
US07423044B2

Reaction notes

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