Methyl 4-(bromomethyl)benzoate → 4-({[6-Isopropyl-2-(3-nitrophenyl)pyrimidin-4-yl]oxy}methyl)benzoic acid

HRID 29916Notes

Reaction equation

HRID 29916 reaction equation
[CH:1]([C:4]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[N:7]=[C:6]([OH:19])[CH:5]=1)([CH3:3])[CH3:2].Br[CH2:21][C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28]C)=[O:27])=[CH:24][CH:23]=1>>[CH:1]([C:4]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[N:7]=[C:6]([O:19][CH2:21][C:22]2[CH:31]=[CH:30][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=2)[CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 178439455HCID 178439455, compound2×

Product 1

HCID 691992894-({[6-Isopropyl-2-(3-nitrophenyl)pyrimidin-4-yl]oxy}methyl)benzoic acid

Procedure

The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and methyl 4-(bromomethyl)benzoate according to Method A and Method B; LC retention time 3.40 min; MS: m/z (ESI) 394 (M+H).

Sources & evidence

ORD record
ord-e161ff5da5ca4b65b5f7decd58f38b5a
Source dataset
uspto-grants-2008_09
Patent number
US07423044B2

Reaction notes

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