Dimethylformamide → Methyl 4-(5-fluoro-6-(3-fluoroazetidine-1-carbonyl)pyridin-3-yloxy)-2,2-dimethyl-2,3-dihydrobenzofuran-6-carboxylate

HRID 299429Notes

Reaction equation

HRID 299429 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[Cs+:36].[Cs+:37].[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH2:12][CH:13]([F:15])[CH2:14]2)[n:4][cH:5][c:6]([F:8])[cH:7]1.[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[OH:16][c:17]1[cH:18][c:19]([C:28](=[O:29])[O:30][CH3:31])[cH:20][c:21]2[c:22]1[CH2:23][C:24]([CH3:26])([CH3:27])[O:25]2>>[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH2:12][CH:13]([F:15])[CH2:14]2)[n:4][cH:5][c:6]([O:16][c:17]2[cH:18][c:19]([C:28](=[O:29])[O:30][CH3:31])[cH:20][c:21]3[c:22]2[CH2:23][C:24]([CH3:26])([CH3:27])[O:25]3)[cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 25067323Methyl 4-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-6-carboxylateHCID 59559983(3,5-Difluoropyridin-2-yl)(3-fluoroazetidin-1-yl)methanone

Product 1

HCID 59559847Methyl 4-(5-fluoro-6-(3-fluoroazetidine-1-carbonyl)pyridin-3-yloxy)-2,2-dimethyl-2,3-dihydrobenzofuran-6-carboxylate

Sources & evidence

ORD record
ord-0f5aed8b8a124d2796ec0543007093de
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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