Phosphorus oxychloride → 1-Chloro-4-(3,4-dimethoxyphenyl)-7-methoxyphthalazine

HRID 29948Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=3)[C:14](=O)[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:14]1[C:15]2[C:20](=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)[C:11]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)=[N:12][N:13]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 692131274-(3,4-dimethoxyphenyl)-7-methoxy-2H-phthalazin-1-one

Product 1

HCID 866122141-Chloro-4-(3,4-dimethoxyphenyl)-7-methoxyphthalazine

Procedure

This compound is obtained according to the procedure described in 1.3. by reacting 4-(3,4-dimethoxyphenyl)-7-methoxy-2H-phthalazin-1-one with phosphoryl chloride.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-a01f10b52b22407ab4d4569ec03a1abc
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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