Dichloromethane → 5'-chloro-2'-fluoro-N-((4-methoxytetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridin-6-amine

HRID 299489Notes

Reaction equation

HRID 299489 reaction equation
[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([N:15]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:23][C:24]3([O:30][CH3:31])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[cH:12][cH:13][cH:14]2)[cH:4][c:5]([F:8])[n:6][cH:7]1.[Cl:39][CH2:40][Cl:41].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38]>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([NH:15][CH2:23][C:24]3([O:30][CH3:31])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[cH:12][cH:13][cH:14]2)[cH:4][c:5]([F:8])[n:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58127426tert-butyl 5'-chloro-2'-fluoro-2,4'-bipyridin-6-yl((4-methoxytetrahydro-2H-pyran-4-yl)methyl)carbamate

Product 1

HCID 581271875'-chloro-2'-fluoro-N-((4-methoxytetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridin-6-amine

Sources & evidence

ORD record
ord-fd6b94e0cc7b440e9cd28b4a70b63a85
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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