4-Amino-1-(2-naphthyl)methylpiperidine → 5,7-dimethoxy-4-(4-methoxyphenyl)-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]phthalazin-1-amine dihydrochloride

HRID 29950Notes

Reaction equation

HRID 29950 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)=[N:4][N:3]=1.[NH2:24][CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:33]=2)[CH2:27][CH2:26]1>>[ClH:1].[ClH:1].[CH3:15][O:14][C:7]1[CH:8]=[C:9]([O:12][CH3:13])[CH:10]=[C:11]2[C:6]=1[C:5]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[N:4][N:3]=[C:2]2[NH:24][CH:25]1[CH2:26][CH2:27][N:28]([CH2:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:33]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 111958234-Amino-1-(2-naphthyl)methylpiperidineHCID 860752924-Chloro-6,8-dimethoxy-1-(4-methoxyphenyl)phthalazine

Product 1

HCID 692093735,7-dimethoxy-4-(4-methoxyphenyl)-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]phthalazin-1-amine dihydrochloride

Procedure

This compound is obtained according to the procedure described in 2.4 by reacting 4-chloro-6,8-dimethoxy-1-(4-methoxyphenyl)phthalazine described in 2.3 with 4-amino-1-(naphthalen-2-ylmethyl)piperidine. On treatment with hydrochloric ether, a precipitate forms, which is filtered off, washed with ethyl ether and dried under reduced pressure. The hydrochloride obtained is in the form of a white solid.

Workup

  1. customThis compound is obtained
  2. filtrationOn treatment with hydrochloric ether, a precipitate forms, which is filtered off
  3. washwashed with ethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-d61b05d1654d40dab85dde057c16e206
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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