1-Bromo-3-chlorobenzene → Tert-butyl 3-(3-chlorobenzoyl)piperidine-1-carboxylate

HRID 299617Notes

Reaction equation

HRID 299617 reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:8])[cH:5][cH:6][cH:7]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:14][O:15][N:16]([C:17](=[O:18])[CH:19]1[CH2:20][N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:22][CH2:23][CH2:24]1)[CH3:32].[CH3:9][CH2:10][CH2:11][CH2:12][Li:13]>>[c:2]1([C:17](=[O:18])[CH:19]2[CH2:20][N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:22][CH2:23][CH2:24]2)[cH:3][c:4]([Cl:8])[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 79281-Bromo-3-chlorobenzeneHCID 8028TetrahydrofuranHCID 22248320Tert-butyl 3-[methoxy(methyl)carbamoyl]piperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 53420072Tert-butyl 3-(3-chlorobenzoyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-d91b84cd69314d55bd1203f21eed803c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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