Hydrochloric Acid → 5-Chloro-6-(3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([I:18])[c:13]([Cl:17])[cH:14][c:15]2[CH2:16]1.[CH:20]12[CH2:21][O:22][CH2:23][CH:24]([CH2:25][CH2:26]1)[NH:27]2.[ClH:19]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([N:27]3[CH:20]4[CH2:21][O:22][CH2:23][CH:24]3[CH2:25][CH2:26]4)[c:13]([Cl:17])[cH:14][c:15]2[CH2:16]1Participants
4
Sources & evidence
- ORD record
- ord-0a0da0bdaf1e43ea923fa948127cddfd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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