Phosphorus oxychloride → 1-Chloro-7-methoxy-4-(4-trifluoromethylphenyl)phthalazine

HRID 29992Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)=[N:8][NH:9][C:10]2=O)=[CH:5][CH:4]=1.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[C:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[N:8][N:9]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 69211513HCID 69211513, compound

Product 1

HCID 877353361-Chloro-7-methoxy-4-(4-trifluoromethylphenyl)phthalazine

Procedure

This compound is obtained according to the procedure described in 1.3. by reacting 7-methoxy-4-(4-trifluoromethylphenyl)-2H-phthalazin-1-one with phosphoryl chloride.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-284c768e513c48239ed08357007183fa
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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