2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(4-methoxymethylbenzoyl)benzoic acid

HRID 30012Notes

Reaction equation

HRID 30012 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.CON(C)[C:21](=[O:31])[C:22]1[CH:27]=[CH:26][C:25]([CH2:28][O:29][CH3:30])=[CH:24][CH:23]=1>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:21](=[O:31])[C:22]2[CH:23]=[CH:24][C:25]([CH2:28][O:29][CH3:30])=[CH:26][CH:27]=2)=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 60645894n-Methoxy-4-methoxymethyl-n-methylbenzamideHCID 178418339Butyllithium

Product 1

HCID 692142505-Methoxy-2-(4-methoxymethylbenzoyl)benzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-4-methoxymethyl-N-methylbenzamide. The product is crystallized from diisopropyl ether.

Workup

  1. customThis compound is synthesized
  2. customThe product is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-a7452d63123c42d1972cb33cffe8ea84
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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