2-Bromo-5-methoxybenzoic acid → 2-(2,5-Dimethoxybenzoyl)-5-methoxybenzoic acid

HRID 30020Notes

Reaction equation

HRID 30020 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH3:18][O:19][C:20]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:21]=1[C:22](N(OC)C)=[O:23]>>[CH3:18][O:19][C:20]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:21]=1[C:22]([C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])=[O:23]

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 18931310HCID 18931310, compoundHCID 178418339Butyllithium

Product 1

HCID 692122442-(2,5-Dimethoxybenzoyl)-5-methoxybenzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 2,5-dimethoxy-N-methoxy-N-methylbenzamide. It is crystallized from diisopropyl ether.

Workup

  1. customThis compound is synthesized
  2. customIt is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-dd638509591b49f5843084af3c32ff33
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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