Phosphorus oxychloride → 1-Chloro-4-(2,5-dimethoxyphenyl)-7-methoxyphthalazine

HRID 30022Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[C:14](=O)[NH:13][N:12]=1.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:14]1[C:15]2[C:20](=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)[C:11]([C:4]2[CH:5]=[C:6]([O:9][CH3:10])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])=[N:12][N:13]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 692090074-(2,5-dimethoxyphenyl)-7-methoxy-2H-phthalazin-1-one

Product 1

HCID 877359031-Chloro-4-(2,5-dimethoxyphenyl)-7-methoxyphthalazine

Procedure

This compound is obtained according to the procedure described in 1.3. by reacting 4-(2,5-dimethoxyphenyl)-7-methoxy-2H-phthalazin-1-one with phosphoryl chloride.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-7f2e581190c94aebb6e03f7050da65c7
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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