Potassium Cation → 7-(2-(1-Tert-butoxycarbonylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

HRID 300451Notes

Reaction equation

HRID 300451 reaction equation
[C:49](=[O:50])([O-:51])[O-:52].[CH3:23][c:24]1[cH:25][cH:26][c:27]([S:28]([O:29][CH2:34][CH2:35][CH:36]2[CH2:37][CH2:38][N:39]([C:42](=[O:43])[O:44][C:45]([CH3:46])([CH3:47])[CH3:48])[CH2:40][CH2:41]2)(=[O:30])=[O:31])[cH:32][cH:33]1.[K+:53].[K+:54].[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[OH:1][c:2]1[c:3]([O:21][CH3:22])[cH:4][c:5]2[c:6](=[O:20])[n:7]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:8][n:9][c:10]2[cH:11]1>>[O:1]([c:2]1[c:3]([O:21][CH3:22])[cH:4][c:5]2[c:6](=[O:20])[n:7]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:8][n:9][c:10]2[cH:11]1)[CH2:34][CH2:35][CH:36]1[CH2:37][CH2:38][N:39]([C:42](=[O:43])[O:44][C:45]([CH3:46])([CH3:47])[CH3:48])[CH2:40][CH2:41]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 10804576(7-Hydroxy-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl pivalateHCID 21936070N-Boc-4-[2-(4-Toluenesulfonyloxy)ethyl]piperidine

Product 1

HCID 110276937-(2-(1-Tert-butoxycarbonylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

Sources & evidence

ORD record
ord-caf751779d4c4b4d98bba5b6fac15007
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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