Phosphorus oxychloride → 1,7-Dichloro-4-(4-methoxyphenyl)phthalazine

HRID 30050Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[N:7][NH:8][C:9]2=O)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:23])=O>>[Cl:23][C:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=2)[C:6]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[N:7][N:8]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 692095087-chloro-4-(4-methoxyphenyl)-2H-phthalazin-1-one

Product 1

HCID 877347451,7-Dichloro-4-(4-methoxyphenyl)phthalazine

Procedure

This compound is obtained according to the procedure described in 1.3. by reacting 7-chloro-4-(4-methoxyphenyl)-2H-phthalazin-1-one with phosphoryl chloride.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-7ddc4698e43d4f2f90e1602e086a0ad7
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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