Hydrochloric Acid → 4-(6-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 300790Notes

Reaction equation

HRID 300790 reaction equation
[CH:1]1([CH2:2][N:12]2[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:20])[c:21]3[nH:22][c:23]4[cH:24][cH:25][cH:26][c:27]([O:30][CH2:31][c:32]5[cH:33][o:34][c:35]6[c:36]5[cH:37][cH:38][c:39]([O:41][CH3:42])[cH:40]6)[c:28]4[cH:29]3)[CH2:16][CH2:17]2)[CH:3]2[N:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:9][CH2:10][CH2:11]1.[ClH:43].[ClH:44].[ClH:45].[NH2:46][CH:47]1[CH2:48][CH2:49][N:50]([CH2:53][CH2:54][N:55]2[CH2:56][CH2:57][CH:58]([OH:61])[CH2:59][CH2:60]2)[CH2:51][CH2:52]1>>[N:12]1([CH2:53][CH2:54][N:55]2[CH2:56][CH2:57][CH:58]([OH:61])[CH2:59][CH2:60]2)[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:20])[c:21]2[nH:22][c:23]3[cH:24][cH:25][cH:26][c:27]([O:30][CH2:31][c:32]4[cH:33][o:34][c:35]5[c:36]4[cH:37][cH:38][c:39]([O:41][CH3:42])[cH:40]5)[c:28]3[cH:29]2)[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid3×HCID 596002201-[2-(4-Aminopiperidin-1-yl)ethyl]piperidin-4-olHCID 178487570N-[1-(2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ylmethyl)piperidin-4-yl]-4-[(6-methoxy-1-benzofuran-3-yl)methoxy]-1H-indole-2-carboxamide

Product 1

HCID 117861124-(6-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Sources & evidence

ORD record
ord-ecaa5921da9e4e6ba37efc1dcc201cd7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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