Acetone → Methyl N-(benzyloxycarbonyl)4-aminomethyl-2-O-benzylsalicylate

HRID 300873Notes

Reaction equation

HRID 300873 reaction equation
[Br:24][CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[C:32](=[O:33])([O-:34])[O-:35].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[NH:11][CH2:12][c:13]1[cH:14][c:15]([OH:23])[c:16]([C:17](=[O:18])[O:19][CH3:20])[cH:21][cH:22]1.[CH3:38][C:39](=[O:40])[CH3:41].[K+:36].[K+:37]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[NH:11][CH2:12][c:13]1[cH:14][c:15]([O:23][CH2:25][c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:16]([C:17](=[O:18])[O:19][CH3:20])[cH:21][cH:22]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 7498Benzyl BromideHCID 19660Carbonate IonHCID 54246052methyl N-(benzyloxycarbonyl)4-aminomethylsalicylate

Product 1

HCID 54469451Methyl N-(benzyloxycarbonyl)4-aminomethyl-2-O-benzylsalicylate

Sources & evidence

ORD record
ord-d2b3cf62d31343438e92b1e2ee555ea3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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