反应详情

温度

145 °C

A solution of 2,6-dichloronicotinic acid (10 g, 46.9 mmol, Aldrich 90%) was dissolved in concentrated ammonium hydroxide (100 mL, 29.4%, Fisher) and heated at 130-160° C. in a pressure bottle for 1-2 days before solvent was removed in vacuo. The residue was treated with water and the pH was lowered to ˜8 with concentrated hydrochloric acid. The resulting mixture was extracted with ethyl acetate and the combined organic extracts were washed with brine, dried, concentrated and the crude product was recrystallized from ethyl acetate to give 2-Amino-6-chloro-nicotinic acid as white crystalline (2.74g, 34 % yield). HRMS, observed: 172.0042, Calcd for M+: 172.0040

1. customwas removed in vacuo
2. additionThe residue was treated with water
3. extractionThe resulting mixture was extracted with ethyl acetate
4. washthe combined organic extracts were washed with brine
5. customdried
6. concentrationconcentrated
7. customthe crude product was recrystallized from ethyl acetate