Hydroxide → 2-[[4-(4-chlorophenyl)sulfonyl-5,8-difluoro-3,4-dihydro-2H-chromen-3-yl]methoxy]ethanol

HRID 300976Notes

Reaction equation

HRID 300976 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][O:11][CH2:12][CH:13]1[CH2:14][O:15][c:16]2[c:17]([F:34])[cH:18][cH:19][c:20]([F:33])[c:21]2[CH:22]1[S:23](=[O:24])(=[O:25])[c:26]1[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]1.[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[H:35][H:36].[OH-:43].[OH-:44].[Pd+2:45]>>[OH:8][CH2:9][CH2:10][O:11][CH2:12][CH:13]1[CH2:14][O:15][c:16]2[c:17]([F:34])[cH:18][cH:19][c:20]([F:33])[c:21]2[CH:22]1[S:23](=[O:24])(=[O:25])[c:26]1[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]1

Participants

6

Reactant 5

HCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 670069033-(2-Benzyloxy-ethoxymethyl)-4-(4-chloro-benzenesulfonyl)-5,8-difluoro-chromanHCID 178418361HCID 178418361, compound

Product 1

HCID 670063802-[[4-(4-chlorophenyl)sulfonyl-5,8-difluoro-3,4-dihydro-2H-chromen-3-yl]methoxy]ethanol

Sources & evidence

ORD record
ord-057c7ccc62c04a70bb9cea76008116d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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