Hydrochloric Acid → Methyl 1-(4-(5-(1-(3,3-difluorocyclobutyl)cyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate

HRID 300978Notes

Reaction equation

HRID 300978 reaction equation
[ClH:28].[F:1][C:2]1([F:27])[CH2:3][CH:4]([C:6]2([c:9]3[cH:10][cH:11][c:12]4[c:13]([n:14]3)[s:15][c:16](-[c:18]3[c:19]([F:26])[cH:20][c:21]([CH:22]=[O:23])[cH:24][cH:25]3)[n:17]4)[CH2:7][CH2:8]2)[CH2:5]1.[NH:29]1[CH2:30][CH:31]([C:33](=[O:34])[O:35][CH3:36])[CH2:32]1>>[F:1][C:2]1([F:27])[CH2:3][CH:4]([C:6]2([c:9]3[cH:10][cH:11][c:12]4[c:13]([n:14]3)[s:15][c:16](-[c:18]3[c:19]([F:26])[cH:20][c:21]([CH2:22][N:29]5[CH2:30][CH:31]([C:33](=[O:34])[O:35][CH3:36])[CH2:32]5)[cH:24][cH:25]3)[n:17]4)[CH2:7][CH2:8]2)[CH2:5]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 20132751Methyl azetidine-3-carboxylateHCID 866387274-(5-(1-(3,3-Difluorocyclobutyl)cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzaldehyde

Product 1

HCID 67112099Methyl 1-(4-(5-(1-(3,3-difluorocyclobutyl)cyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate

Sources & evidence

ORD record
ord-2b517017675f4910880a3805384a0679
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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