反应详情

To a solution of 2-iodoanisole (4.97g, 21.24 mmol, Aldrich 98%) in anhydrous tetrahydrofuran (33 mL) at −78° C., was added a solution of n-butyllithium in hexane (2.5 M, 8.5 mL, 21.25 mmol, Aldrich). The reaction was stirred at −78 OC for 0.5-1 hr to give a solution of the 2-methoxyphenyl lithium for the following reaction.