Methyl Isocyanate → 4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide
Reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[O:9])=[CH:6][CH:5]=[C:4]([NH:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:3]=1.[CH3:24][N:25]=[C:26]=[O:27]>>[CH3:24][NH:25][C:26]([N:21]1[CH2:20][CH2:19][CH:18]([NH:17][C:4]2[CH:5]=[CH:6][C:7]([C:8](=[O:9])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[F:16])=[C:2]([NH2:1])[N:3]=2)[CH2:23][CH2:22]1)=[O:27]Participants
3
Procedure
The title compound was prepared from [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone (Example 9) and methyl isocyanate (Aldrich 98%) using the procedure described in Example 12. HRMS, observed: 371.1756, calcd for M+: 371.1758.
Sources & evidence
- ORD record
- ord-7f348728482c4c748c3c573a57f63d06
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07423051B2
Reaction notes
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