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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30114Generated: October 25, 2026

Methyl Isocyanate → 4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide

https://huagongshe.com/reaction/30114

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl IsocyanateHCID 12228—
Reactant[2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanoneHCID 58590835—
Product4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamideHCID 11545207—

Reaction Steps

The title compound was prepared from [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone (Example 9) and methyl isocyanate (Aldrich 98%) using the procedure described in Example 12. HRMS, observed: 371.1756, calcd for M+: 371.1758.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423051B2
Source datasetuspto-grants-2008_09
ORD IDord-7f348728482c4c748c3c573a57f63d06
Source noteuspto-grants-2008_09