Acetyl chloride → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Acetyl chloride	HCID 6367	—
Reactant	[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt	HCID 21070627	—
Product	1-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone	HCID 11653917	—

Reaction Steps

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and acetyl chloride (Aldrich 98.5%) using the procedure described in Example 24. HRMS, observed: 387.1833, Calcd for (M+H)+: 387.1827.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07423051B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-9a1d573ea0bf4a6aa58bc6cbb1b37522
Source note	uspto-grants-2008_09