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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30129Generated: October 26, 2026

Methyl Isocyanate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide

https://huagongshe.com/reaction/30129

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl IsocyanateHCID 12228—
Reactant[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid saltHCID 21070627—
Product4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamideHCID 11545824—

Reaction Steps

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and methyl isocyanate (Aldrich, 98%) using the procedure described in Example 24. HRMS, observed: 402.1940, Calcd for (M+H)+: 402.1936.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423051B2
Source datasetuspto-grants-2008_09
ORD IDord-679e22877aea40898d3601f9b5da6384
Source noteuspto-grants-2008_09