1-Bromo-4,5-difluoro-2-methoxybenzene → (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone

HRID 30136Notes

Reaction equation

HRID 30136 reaction equation
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].Br[C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[O:24][CH3:25]>>[NH2:1][C:2]1[C:3]([C:4]([C:18]2[C:17]([O:24][CH3:25])=[CH:16][CH:21]=[C:20]([F:22])[C:19]=2[F:23])=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

Participants

3

Reactant 2

HCID 27362621-Bromo-4,5-difluoro-2-methoxybenzeneHCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

Product 1

HCID 58590826(2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone

Procedure

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 2-bromo-4,5-difluoroanisole (Apollo) using the procedure described in Example 7. HRMS, observed: 298.0318, Calcd for M+: 298.0321.

Sources & evidence

ORD record
ord-9e1bdbd13d854f31bcd46bf3854489c4
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Reaction notes

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