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HRID30137

反应详情

EQUATION

反应方程式

HRID 30137 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)N1CCC(N)CC1
HCID11355826

1-(Methanesulfonyl)piperidin-4-amine

C6H14N2O2S

结构：COc1ccc(F)c(F)c1C(=O)c1ccc(Cl)nc1N
HCID58590826

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(F)c(F)c1C(=O)c1ccc(NC2CCN(S(C)(=O)=O)CC2)nc1N
HCID11597358

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 39) and 1-methanesulfonyl-piperidin-4-ylamine (Step A. Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 441.1407, Calcd for (M+H)+: 441.1403. Ki for cdk4=0.017 μM, cdk1=0.060 μM, cdk2=0.054 and IC50 for HCT116 cell line=2.6 μM.