HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Methanesulfonyl)piperidin-4-amine → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Methanesulfonyl)piperidin-4-amine | HCID 11355826 | — |
| Reactant | (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone | HCID 58590826 | — |
| Product | [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone | HCID 11597358 | — |
Reaction Steps
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 39) and 1-methanesulfonyl-piperidin-4-ylamine (Step A. Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 441.1407, Calcd for (M+H)+: 441.1403. Ki for cdk4=0.017 μM, cdk1=0.060 μM, cdk2=0.054 and IC50 for HCT116 cell line=2.6 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423051B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-6ba95a377bb14a658d85e0dcd2a5c19d |
| Source note | uspto-grants-2008_09 |