1-Bromo-2,6-difluorobenzene → (2-Amino-6-chloro-pyridin-3-yl)-(2,6-difluoro-phenyl)-methanone

HRID 30148Notes

Reaction equation

HRID 30148 reaction equation
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].Br[C:16]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=1[F:23]>>[NH2:1][C:2]1[C:3]([C:4]([C:16]2[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=2[F:23])=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

Participants

3

Reactant 2

HCID 1235571-Bromo-2,6-difluorobenzeneHCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

Product 1

HCID 58590833(2-Amino-6-chloro-pyridin-3-yl)-(2,6-difluoro-phenyl)-methanone

Procedure

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 2-bromo-1,3-difluorobenzene (Aldrich) using the procedure described in Example 7. HRMS, observed: 268.0217, Calcd for M+: 268.0215.

Sources & evidence

ORD record
ord-01d5fbb683b94a4b84c9036e8c746f35
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Reaction notes

Loading…