1-(Bromomethyl)-2-(trifluoromethyl)benzene → 6-Fluoro-2'-oxo-1'-[2-(trifluoromethyl)benzyl]-1',2'-dihydrospiro[1-benzofuran-3,3-indole]-5-carbonitrile
Reaction equation
[Br:13][CH2:14][c:15]1[o:16][c:17]([C:18]([F:19])([F:20])[F:21])[cH:22][cH:23]1.[CH3:45][c:46]1[c:47]2[cH:48][c:49]3[c:62]([cH:63][c:64]2[o:65][n:66]1)[O:61][CH2:60][C:50]31[c:51]2[c:52]([cH:53][cH:54][cH:55][cH:56]2)[NH:57][C:58]1=[O:59].[F:1][C:2]([c:3]1[c:4]([CH2:5][Br:6])[cH:7][cH:8][cH:9][cH:10]1)([F:11])[F:12].[F:24][c:25]1[cH:26][c:27]2[c:28]([cH:41][c:42]1[C:43]#[N:44])[C:29]1([CH2:30][O:31]2)[C:32](=[O:40])[NH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]21>>[F:1][C:2]([c:3]1[c:4]([CH2:5][N:33]2[C:32](=[O:40])[C:29]3([c:28]4[c:27]([cH:26][c:25]([F:24])[c:42]([C:43]#[N:44])[cH:41]4)[O:31][CH2:30]3)[c:39]3[c:34]2[cH:35][cH:36][cH:37][cH:38]3)[cH:7][cH:8][cH:9][cH:10]1)([F:11])[F:12]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-ecc23edec56542a18ce46a208758fb6b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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