Dicyclohexylcarbodiimide → (RS)-2-[5-(3-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine 1-carboxylic acid tert butyl ester
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:18][C:19]1[CH:20]=[C:21]([C:25]2NN=[N:27][N:26]=2)[CH:22]=[CH:23][CH:24]=1.C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:17][C:25]([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[CH:20]=2)=[N:26][N:27]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]Participants
4
Procedure
The title compound ((1.28 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (1.48 g), 5-(3-fluorophenyl)tetrazole (1.0 g) and dicyclohexylcarbodiimide (1.25 g) according to the method of description 1.
Sources & evidence
- ORD record
- ord-74f40c3f600a43d1b42e4413005766d6
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07423052B2
Reaction notes
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