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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30165Generated: October 27, 2026

Dicyclohexylcarbodiimide → (RS)-2-[5-(3-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine 1-carboxylic acid tert butyl ester

https://huagongshe.com/reaction/30165

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
Reactant1-Boc-2-Piperidineacetic AcidHCID 5058536—
ReactantHCID 178505664HCID 178505664—
Product(RS)-2-[5-(3-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine 1-carboxylic acid tert butyl esterHCID 86628997—

Reaction Steps

The title compound ((1.28 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (1.48 g), 5-(3-fluorophenyl)tetrazole (1.0 g) and dicyclohexylcarbodiimide (1.25 g) according to the method of description 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423052B2
Source datasetuspto-grants-2008_09
ORD IDord-74f40c3f600a43d1b42e4413005766d6
Source noteuspto-grants-2008_09