(RS)-4-{1-[5-(4-Fluorophenyl)-2-methylthiazol-4-yl]-methanoyl}-3-[4-(4-fluoro-phenyl)-oxazol-2-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester → 1-[5-(4-Fluorophenyl)-2-methyl-thiazol-4-yl]1-{2-[4-(4-fluorophenyl)-oxazol-2-ylmethyl]-piperazin-1-yl}-methanone

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4-{1-[5-(4-Fluorophenyl)-2-methyl-tliiazol-4-yl]-methanoyl}-3-[4-(4-fluoro-pbenyl)-oxazol-2-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester (0.130 g) was dissolved in trifluoroacetic acid (10 ml) and stirred at rdom temperature for 2 hours. The reaction mixture was then evaporated to dryness at reduced pressure and the residue was chromatographed over silica gel. Elution with a gradient of 0 to 10% [9:1 methanol/conc. ammonia solution] in dichloromethane provided the title compound as a pale yellow gum (0.013 g), mass spectrum (API+) 481 [MH+], C25H22F2N4O2S requires 480.

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