Methanol → 5-Bromo-3-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methylpyridin-2(1H)-one
Reaction equation
[Br:13][c:14]1[c:15](=[O:22])[n:16]([CH3:21])[cH:17][c:18]([Br:20])[cH:19]1.[C:23](=[O:24])([O-:25])[O-:26].[CH2:30]1[O:31][CH2:32][CH2:33][O:34][CH2:35]1.[CH3:92][OH:93].[CH3:97][CH2:98][O:99][C:100]([CH3:101])=[O:102].[CH:38](=[CH:39][C:40]([CH:41]=[CH:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)=[O:49])[c:50]1[cH:51][cH:52][cH:53][cH:54][cH:55]1.[CH:56](=[CH:57][C:58]([CH:59]=[CH:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1)=[O:67])[c:68]1[cH:69][cH:70][cH:71][cH:72][cH:73]1.[CH:74](=[CH:75][C:76]([CH:77]=[CH:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1)=[O:85])[c:86]1[cH:87][cH:88][cH:89][cH:90][cH:91]1.[Cl:94][CH2:95][Cl:96].[Cs+:27].[Cs+:28].[NH2:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH:10]([OH:12])[CH2:11]2)[cH:6][n:7]1.[OH2:29].[Pd:36].[Pd:37]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH:10]([OH:12])[CH2:11]2)[cH:6][n:7]1)[c:14]1[c:15](=[O:22])[n:16]([CH3:21])[cH:17][c:18]([Br:20])[cH:19]1Participants
12
Reactant 11
Product 1
Sources & evidence
- ORD record
- ord-55cfba2cedd64c80a4e3b658aa2ca405
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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