Potassium Hydroxide → HCID 11651418, compound

HRID 30242Notes

Reaction equation

HRID 30242 reaction equation
C(OC([N:6]1[CH2:13][CH:12]2[CH:8]([CH2:9][C:10]3[C:16]([Cl:17])=[C:15]([CH3:18])[S:14][C:11]=32)[CH2:7]1)=O)C.[OH-].[K+]>CCO.C(Cl)Cl>[Cl:17][C:16]1[C:10]2[CH2:9][CH:8]3[CH:12]([C:11]=2[S:14][C:15]=1[CH3:18])[CH2:13][NH:6][CH2:7]3

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 131727024HCID 131727024, compound

Product 1

HCID 11651418HCID 11651418, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

The product of step d) was treated with 40% aqueous KOH in EtOH at 105° C. for 16 hours. The reaction was cooled, diluted with CH2Cl2 and passed through an extrelut column to remove the water. The organic layer was concentrated and the residue purified by preparative LC/MS to give the title compound. MS calculated for C10H12ClNS+H 214, observed 214.

Workup

  1. temperatureThe reaction was cooled
  2. customto remove the water
  3. concentrationThe organic layer was concentrated
  4. customthe residue purified by preparative LC/MS

Sources & evidence

ORD record
ord-42e4da9170d742b8a5b27248ef620543
Source dataset
uspto-grants-2008_09
Patent number
US07423056B2

Reaction notes

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