HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1,1-Dimethylethyl 4-(4,5-dibromo-2-thienyl)-1-(phenylmethyl)-3-pyrrolidinecarboxylate | HCID 67207338 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate | HCID 67206234 | — |
Reaction Steps
The product of step b) (2.6 g, 5.2 mmol) in CH2Cl2 (25 ml) and trifluoroacetic acid (TFA) (75 ml) was stirred at 220C for 16 hours. Next, the solvent was evaporated and toluene (50 ml) was added and subsequently evaporated in vacuo at 40° C. to remove residual TFA. The crude subtitle product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423056B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-f2679f0a7f1446b1be68aeff2407dc97 |
| Source note | uspto-grants-2008_09 |