Dichloromethane → N-tert-butyl-3-[(2-methylpiperazin-1-yl)methyl]benzamide

HRID 302639Notes

Reaction equation

HRID 302639 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][c:10]([CH2:11][N:12]2[CH:13]([CH3:25])[CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]2)[cH:26][cH:27][cH:28]1.[Cl:36][CH2:37][Cl:38].[F:29][C:30]([F:31])([F:32])[C:33]([OH:34])=[O:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][c:10]([CH2:11][N:12]2[CH:13]([CH3:25])[CH2:14][NH:15][CH2:16][CH2:17]2)[cH:26][cH:27][cH:28]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 76640955Tert-butyl 4-[[3-(tert-butylcarbamoyl)phenyl]methyl]-3-methylpiperazine-1-carboxylate

Product 1

HCID 66878706N-tert-butyl-3-[(2-methylpiperazin-1-yl)methyl]benzamide

Sources & evidence

ORD record
ord-29dc01bac09e4fa49aabb8ac22f68103
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…